Anti-multidrug resistance

Lathyrol
Catalog No: CFN98115

Lathyrol diterpenes is a modulator of P-glycoprotein dependent multidrug resistance, and is used for cancer treatment.

Epoxylathyrol
Catalog No: CFN98559

Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells.

Cepharanthine
Catalog No: CFN98570

Cepharanthine has anti-plasmodial, anti-tumor , anti-inflammatory, antiallergic, antioxidant, and immunomodulatory activities in vivo, and it is a highly potent inhibitor of HIV-1 replication in a chronically infected monocytic cell line. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral infection.

Estrone
Catalog No: CFN90042

Estrone,a steroid known to play an important role as precursor of 17 beta-estradiol,especially in postmenopausal women, it inhibits the BCRP-mediated drug efflux and overcome drug resistance.The widely distributed estrone esters in food and their relatively high concentrations may result in high free hormone intakes in humans, the continued and massive intake of estrone may enhance tissue deposition and lead to obesity.

Sarpagine
Catalog No: CFN98759

Sarpagine is effective in reversing multidrug-resistance (MDR) in vincristine-resistant KB cells.